True or False: The VEX Cortex should be powered OFF when you connect it to the computer.

The VEX Cortex should indeed be powered OFF when connecting it to the computer. This precaution is important because it helps prevent any potential damage to the controller or the computer during the connection process. When the Cortex is powered on, it may inadvertently send signals or receive commands that could interfere with the programming or firmware update process. By ensuring that the device is powered off, you create a safe environment to establish a reliable communication link without the risks associated with power-related issues.

In terms of the other choices, it is not the case that the Cortex can be safely powered on during routine connections, nor is it limited to just firmware updating scenarios. The idea that it "does not matter" reflects a misunderstanding of the proper protocol for connecting electronic devices like the Cortex to avoid complications. Thus, turning off the Cortex before making any connection with the computer maintains device integrity and ensures successful interaction with the programming software.