True or False: Single-line comments can greatly affect the execution of a program.

Single-line comments are meant for providing annotations and clarifications within the code to improve readability and understanding for anyone reviewing it. They are not executed as part of the program; the compiler or interpreter ignores these comments completely. Therefore, they do not influence the actual operation or outcome of the program, making the statement false.

While comments can be extensive or placed in various positions, they remain non-executable and do not affect program execution regardless of their characteristics or placements. This understanding is fundamental in programming, as it highlights the distinction between code meant for execution and ancillary notes meant for human reference.